While Owen Farrell captains the group in fly-half ruaridh McConnochie has been appointed to start following two false starts for England.
The uncapped McConnochie was scheduled to begin against Wales in a pair of World Cup warm-up fixtures last month, but pulled from the two games due to injury.
The Bath winger will make his debut England face Italy in their at Newcastle, live on Sky Sports.
The No 10 jersey George Ford chooses his place on the bench, while Piers Francis begins at inside centre is worn by farrell.
More to follow…
England: 15 Anthony Watson, 14 Ruaridh McConnochie, 13 Joe Marchant, 12 Piers Francis, 11 Jonny May, 10 Owen Farrell (c), 9 Ben Youngs, 1 Joe Marler, two Jamie George, 3 Dan Cole, 4 Joe Launchbury, 5 Courtney Lawes, 6 Tom Curry, seven Mark Wilson, 8 Billy Vunipola.
Replacements: 16 Luke Cowan-Dickie, 17 Ellis Genge, 18 Kyle Sinckler, 19 Charlie Ewels, 20 Matt Kvesic, 21 Willi Heinz, 22 George Ford, 23 Joe Cokanasiga.
Read more here: None